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KMID : 0606920080160010009
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Biomolecules & Therapeutics
2008 Volume.16 No. 1 p.9 ~ p.13
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Antioxidant and Anti-Nociceptive Activities of Ulmus davidiana var. japonica
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Jung Hyun-Joo
Kang Hyun-Jung
Song Yun-Seon
Lim Chang-Jin
Park Eun-Hee
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Abstract
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Some pharmacological activities of Ulmus davidiana var. japonica were evaluated using its methanol extract (UDE). An acute anti-inflammatory activity of UDE was assessed using carrageenan-induced hind paw edema in rats. UDE exhibited an antioxidant activity when assayed by a stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). Dose-dependent anti-nociceptive activity of UDE was assessed using the acetic acid-induced writhing test in mice. UDE was able to diminish the reactive oxygen species (ROS) level in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. UDE also suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the stimulated macrophages cells. collectively, the results imply that U. davidiana var. japonica has antioxidant and anti-nociceptive activities in addition to anti-inflammatory activity.
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KEYWORD
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Ulmus davidiana var. japonica, anti-nociceptive, anti-inflammatory, antioxidant, nitric oxide, reactive oxygen species
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